What determines the "release" is more about the medication's packaging (uncoated, coated tab, gel cap or capsule), than the med itself. Where it releases also determines the amount of systemic effects it has on your body......so it really depends on what part of your body you want the med to act on and how bad the med would be if it were allowed to act on your whole body. I'd suggest you talk with your Doc and find out specifically where he's targeting with each med and how does he know it's being released in that area. I have taken meds that came out whole and "un-released". I decided to "help" release the meds earlier by biting the tabs in half before swallowing, or cracking the capsule with my teeth before swallowing. I'm not recommending you do that until you better understand what the impact on your body would be if they released too early. You need to be careful because some meds you absolutely do not want releasing in your stomach and being spread thru your whole bloodstream and body. Most meds can be compounded in different release packaging, but some cannot due to patent protections. For those that cannot, you can follow my example (if recommended by your Doc). Speeding up the release is much easier than trying to delay it.