This topic is about dealing with a small cut or sore that is bleeding under a Hollister two-piece ostomy appliance. The person is worried about the risk of infection and is unsure how to treat the wound, especially since it is covered by the appliance. They are considering using Neosporin but are uncertain about its effectiveness and how long it would last under the appliance. Here are some helpful tips and advice:

1. First, verify the source of the bleeding:
- Use a small hand mirror to check underneath the stoma. Minor bleeding from the stoma is common, especially if the wafer opening has rough edges or if stitches are still present.
- If the bleeding is heavy or doesn't stop, reach out to your stoma nurse or doctor.

2. Treat minor skin nicks with ostomy supplies rather than ointments:
- Sprinkle ostomy or stoma powder on the area, then seal it with a skin-barrier film or wipe using the "crusting method."
- Use ostomy paste during bag changes to protect an over-healed, easily bleeding spot.
- Some healthcare providers might cauterize an area that bleeds repeatedly.

3. Avoid products that interfere with adhesion:
- Neosporin and most ointments can leave an oily film that prevents wafers from sticking properly, and some people are allergic to Neosporin.
- Instead, wash the area with mild soap and water during each change and let it dry completely.

4. Consider alternative soothing products:
- Vicks VapoRub can be applied sparingly, followed by stoma powder and a barrier wipe, to calm irritated skin when the wafer or barrier ring isn’t snug enough.
- Calamine lotion can be used, but make sure it dries completely before applying the pouch.

5. Practical tips to reduce future irritation:
- Ensure the cut edge of a custom-cut wafer is smooth to prevent rubbing and bleeding.
- Shave the area carefully to avoid accidental cuts.
- Make sure the barrier ring and wafer fit snugly against the stoma to prevent waste from pooling on the skin.
- Eating marshmallows shortly before appliance changes may slow stoma output, making inspection and clean-up easier.