Topic Explanation
The discussion centers around the absorption of the medications mirtazapine and pregabalin in individuals with an ileostomy, which involves the removal of the colon. The original poster is seeking information on whether these medications are effectively absorbed without a colon.

Advice and Insights
1. Absorption of Mirtazapine and Pregabalin:
- Mirtazapine is primarily absorbed in the small intestine, reaching peak plasma concentrations within about 2 hours after oral administration.
- Pregabalin is absorbed in the small intestine and proximal colon in a linear and dose-proportional manner. Differences exist between controlled-release and immediate-release formulations.
- Controlled-release medications are generally not recommended for individuals with an ileostomy.

2. Medication Form and Absorption:
- Time-release medications may not be effective for those with an ileostomy as they do not stay in the system long enough to be absorbed.
- Gel caps and certain medications may pass through the system undigested, which can be observed if they appear whole in the ostomy bag.
- Liquid forms of medications are often recommended for better absorption.

3. Self-Monitoring and Consultation:
- It is important to be self-aware and monitor whether medications are providing the intended benefits.
- If medications appear undigested in the ostomy bag or if there is no perceived benefit, it is advisable to consult with a healthcare provider.
- Pharmacists can provide valuable information on drug absorption and alternative formulations, such as liquid forms.

4. Personal Experiences and Adjustments:
- Some individuals have switched from gel caps to liquid forms of supplements and medications due to absorption issues.
- Adjustments in medication forms, such as switching from time-release to immediate-release or liquid forms, can be necessary based on personal absorption experiences.
- Consulting with healthcare providers, including pharmacists, can help in determining the best medication forms and dosages.

5. General Advice:
- Discuss any concerns about medication absorption with a pharmacist or medical team.
- Consider the potential need for medication adjustments if experiencing increased symptoms or lack of efficacy.
- Be open to trying different forms of medication to find what works best for individual absorption needs.