This topic is about exploring the use of Ozempic for weight loss in individuals who have a permanent ileostomy. The person sharing their story has faced challenges with weight gain after transitioning to a less active lifestyle and is curious about the potential benefits and risks of using Ozempic. They are also seeking insights from others who might have similar experiences. Here are some helpful points and advice gathered from the discussion:

- Absorption & Hydration
- There is no evidence to support the idea that the small intestine absorbs more fat after a colectomy. The consistency and volume of output are still largely influenced by diet.
- People with an ileostomy are generally at a higher risk for dehydration and loss of minerals like iron and magnesium. A good rule of thumb is to replace any fluid lost by drinking an equivalent amount.

- Non-drug weight-control strategies that have worked
- Engage in moderate exercise that is safe for those with a hernia risk, such as using a recumbent stationary bicycle, lifting 5-pound hand weights, or taking 30-minute daily walks.
- Focus on calorie control by limiting carbohydrates and sugars, and try to eat smaller portions even when the food is tempting.

- Experiences with Ozempic (semaglutide)
- Positive outcome: One person reported losing weight and maintaining it for 1-2 years after initially undergoing gastric-sleeve surgery and then using Ozempic. They described it as a "miracle."
- Caution: Significant weight loss can result in excess abdominal skin, which may interfere with pouch adhesion and cause leaks. Getting insurance approval for skin removal surgery can be challenging.
- Negative/mixed outcomes: Some users experienced side effects when using Ozempic primarily for weight loss, such as severe bloating, aches, blurry or painful eyes, sore shoulder joints, and bruised injection sites.
- One person gained 2 pounds over six weeks on Ozempic and stopped using it with their doctor's agreement.
- Another individual switched from Ozempic to Farxiga for diabetes management, which helped with blood sugar but not with weight loss.

- General cautions
- It is important to discuss the risks, benefits, and off-label use of Ozempic for weight loss with a physician, as people without diabetes may have different risk profiles.
- If significant weight loss is achieved, be prepared for potential skin issues around the stoma that could affect the fit of the appliance.